Comparing Ophthalmic and Microscopic Findings in the Patients of Psuedo Exfoliative Syndrome With and Without Glaucoma in a Tertiary Care Referral Hospital of Western Himalayas: An Analytical Cross-Sectional Study

Abstract

Pseudoexfoliation is an age-related systemic disorder with primary ocular manifestation having strong genetic component liking to LOXL-1 gene.The findings from Non-Contact Specular Microscope such as Central corneal thickness (CCT) in subjects with PEX and PEXG, are conflicting.The present cross-sectional analytical study was conducted in the Department of Ophthalmology, Indira Gandhi Medical College, Shimla among the selected patients of pseudo exfoliation with glaucoma over a period of one year with an objective of comparing the ocular as well as intra ocular manifestations among the patients suffering from PEX in comparison to PEXG attending an ophthalmic Out Patient Department clinic. There were 46 study participants in each group of which there were 24 males and 22 females in PEX and 32 males and 14 females in PEXG group. The mean age of patients with Pseudoexfoliation without Glaucoma was 68.43±9.88while that of the patients with glaucoma was 66.52 ± 8.38 years. The mean vertical cup disc ratio of PEX patients was 0.36±0.14 while that of patients of PEXG was 0.84±0.32.There was no significant difference in the central corneal thickness (p=0.492) and the coefficient of variation (p=0.310) between both the groups.