Abstract
Background: Heart Rate Variability (HRV) surrogates for Cardiac Autonomic Modulation (CAM), while Pulse Rate variability (PRV) reflects Cardiovascular Autonomic Modulation (CvAM). HRV and PRV therefore, are not exactly interchangeable terms. However, the paper proposes that PRV and HRV can be correlated. Aim: To compare the correlation between two different instruments â (I) gold-standard Polar H10 HRV sensor that works on the principle of CAM and Kubios software for HRV estimation, together called âPKâ and (II) Lyfas smartphone application called âLâ, which estimates PRV that reflects the state of CvAM. Methods: Parameters, such as (i) HR, (ii) RMSSD, (iii) pNN50, (iv) SDNN, and (v) LF/HF are captured from a total of 567 healthy Indian adults (312 males and 255 females) using PK and L simultaneously. End HR data (120 sec) are then compared instrument and gender-wise statistically by computing the i) RMSE, ii) Regressions (L on PK), iii) a Two-sample t-test, and (iv) classification accuracy of L when compared to PK. Finally, the Sensitivity/recall (R), Specificity (S), Precision (P), Accuracy (A), F score (F), and Youdenâs index (Y) are computed for L. Results: L shows encouraging averages for males and females respectively âRâ (84%, 70%), âSâ (95%, 87%), âAâ (82%, 79%), âPâ (87%, 69%),âFâ (1.4836, 1.3706) and âYâ (79%, 81%) for HR, SDNN, RMSSD, and pNN50 respectively. Conclusions: Although âLâ has 1/33th times less resolution compared to PK, its technical efficacy, speed, user-friendliness, low-cost-benefit, high âYâ values, and ubiquitousness pose a great advantage in its deployment in the clinical setup as a biomarker tool over PK.
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