Abstract
Most of chemical drugs have side effects on various parts of body. It is necessary to identify these effects to better use of drugs. Betamethasone and Dexamethasone are two of the most usual drugs in human and animal medication. The effect of these drugs on concentration of male reproductive hormones of mice was the goal of this study. Eighteen matured male mice were divided into eight groups including control, placebo and six treatment groups. Placebo group was received physiological serum only and treatments were Betamethasone (0.1, 0.5 and 1 mg/kg) and Dexamethasone (0.1, 0.5 and 1 mg/kg) which were injected in peritoneum every other day and for twenty days. After 20 days, blood samples were taken and FSH, LH and testosterone levels were measured using Eliza test method. Obtained data were analyzed using one way analysis of variance and mean comparison was done using Duncan's multiple ranges test and SPSS program. Results showed that 0.5 mg/kg of Betamethasone and all levels of dexamethasone caused significant increase in FSH concentration. For LH hormone, 1 mg/kg of Betamethasone and 0.1 mg/kg of Dexamethasone caused significant decrease whereas 1 mg/kg of Dexamethasone increased it significantly. Testosterone was increased significantly by 1 mg/kg of Dexamethasone. So, mentioned drugs are effective on hormone action of reproductive system dose dependently and probable effect of them must be considered in time of using.
Highlights
Dexamethasone is a synthetic glucocorticoid with 50 times more tendency than cortisol to conjunct with glucocorticoid receptor
In a study for determining various effects of Dexamethasone on inflammation of lipopolysaccharide and controlling sexual hormones in matured mice reported that Dexamethasone suppressed cortikostron level of serum but didn’t affect LH and testosterone level of serum and it controlled the expression of interlukin 1 β and response of inflammatory system (Hedger et al, 2001)
Betamethasone and Dexamethasone drugs were used each in three doses: 0.1, 0.5 and 1 mg/kg which were injected in peritoneum
Summary
Dexamethasone is a synthetic glucocorticoid with 50 times more tendency than cortisol to conjunct with glucocorticoid receptor. In a study for determining various effects of Dexamethasone on inflammation of lipopolysaccharide and controlling sexual hormones in matured mice reported that Dexamethasone suppressed cortikostron level of serum but didn’t affect LH and testosterone level of serum and it controlled the expression of interlukin 1 β and response of inflammatory system (Hedger et al, 2001). Betamethasone is a corticostroide which is proposed for lung maturity of embryos in danger of Preterm birth. It is proposed in 24 to 34 weeks of pregnancy and has effect like reduction in appearance of respiratory distress syndrome; death caused by brain bleeding and increases in probability of live babies. This study was conducted to compare effects of Betamethasone and Dexamethasone on concentration of sexual hormones in male mice
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