Abstract
The purpose of this study was to reveal the molecular mechanism that regulates fat metabolism in hump of Bactrian camel. The subcutaneous fat (SF), greater omentum (GOM) and hump fat (HF) of Bactrian camel were sequenced by RNA sequencing, and the differentially expressed genes of fat tissue in 3 different parts at transcriptome level were obtained by paired comparison. Genes related to fat metabolism were screened out, among which HF vs. GOM group had the largest number of different genes related to fat metabolism. Some genes such as SCD, FASN, ACACA, ADIPOQ, PLIN1, PLIN4, LPL and HSL were highly expressed in HF. These genes may play an important role in maintaining the energy homeostasis of Bactrian camels in the absence of food. Signaling pathway analysis revealed a number of pathways involved in fat metabolism including AMPK signaling pathway, PPAR signaling pathway, Adipocytokine signaling pathway, ECM-receptor interaction and regulation of lipolysis in adipocytes. These data suggests HF has a greater capacity to modulate the release and storage of triglycerides in adipocytes than GOM.
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