Comparative study to evaluate efficacy of IV infusion of dexmedetomidine versus IV infusion of propofol for post-operative ICU sedation

Abstract

Aim: The purpose of the present study is to evaluate the efficacy of dexmedetomidine and propofol as an IV infusion for post-operative ICU sedation. Methodology: This study was performed on Dr. Moopen's Medical College, Wayanad, Kerala. India and duration was from January 2022 to September 2022. Thirty patients who were ambulatory and who required the post-operative mechanical ventilation or post-operative sedation were enrolled, in which 15 patients received Dexmedetomidine and remaining 15 patients received propofol. All these patients were treated for the period of 8 to 24 h. Data were analyzed using Student’s t-test and Chi-square test. The value of P < 0.05 was considered as statistically significant. Results: Demographic data were comparable. Pulse rate, respiratory rate and blood pressure were comparable. Depth of sedation and extubation time were similar. To maintain analgesia throughout the study period, patients receiving propofol infusions required significantly more analgesics than patients receiving Dexmedetomidine. Conclusion: Dexmedetomidine appears to be a safe and acceptable ICU sedative agent when both the clinician’s and patient’s perspectives are considered.