Abstract
In this study, we compared the in vitro antioxidant property among the selected Ocimum species (O. sanctum, O. americanum, O. basilicum and O. gratissimum) and hepatoprotective activities of their extracts against CCl4 induced intoxication. The results suggested that the four species of Ocimum genus showed variability in Phenolic content and in vitro antioxi-dant activity against DPPH, superoxide and hydroxyl radicals in the following manner: O. sanctum > O. americanum > O. basilicum > O. gratissimum respec-tively. Based on serum AST, ALT, ALP and T. Bil levels, the alcoholic extracts of Ocimum species showed a significant dose dependent (250 mg and 500 mg and 750 mg/kg p.o.) and a protective effect against CCl4 induced hepatotoxicity in albino rats. The results further revealed that the potential hepatoprotective activity of Ocimum sanctum among the Ocimum species.
Highlights
The liver is the most important organ concerned with the biochemical activities in the human body
The results suggested that the four species of Ocimum genus showed variability in Phenolic content and in vitro antioxidant activity against DPPH, superoxide and hydroxyl radicals in the following manner: O. sanctum > O. americanum > O. basilicum > O. gratissimum respectively
The results further revealed that the potential hepatoprotective activity of Ocimum sanctum among the Ocimum species
Summary
The liver is the most important organ concerned with the biochemical activities in the human body. Reactive oxygen species are implicated in liver damage [2] through covalent binding and lipid peroxidation and have been shown to augment fibrosis as seen from increased collagen synthesis [3]. Scavenging of free radicals by antioxidants could reduce the fibrosis process in the tissues [4]. Ocimum sanctum is known to possess anti-inflammatory, antimicrobial, antidiabetic, hepatoprotective, cardioprotective, antioxidant, adaptogenic, anticancer and radioprotective activities. There are other species in the same genus (Ocimum) and its influence on hepatoprotective activity is not established scientifically. The selected four species O. sanctum, O. americanum, O. basilicum and O. gratissimum were subjected to the estimation of total phenolic content, antioxidant activity and evaluated for hepatoprotective activity
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