Abstract
This paper presents a comparative analysis of the combined and separate influence of ultrasound and DMSO on the transport of a gold nanoshell suspension in intact and injured skin from data on optical coherence tomography and histochemical analysis. Experimental allergic contact dermatitis was used to model injury to the stratum corneum during various pathological changes in the skin. The studies were performed on outbred laboratory rats. It is shown that the best method for enhancing transdermal transport of an immersion liquid is multimodal physical and chemical impact (a combination of DMSO and ultrasonophoresis); the effectiveness of optical clearing of the dermis both in the presence and absence of the stratum corneum is approximately the same. To enhance the transport of nanoparticles into the skin when it undergoes pathological changes related to injuries of the protective barrier, exposure to ultrasound is sufficient.
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