Comparative study of serum calcium and serum magnesium levels in patients of preeclampsia and normotensive patients

Abstract

Introduction: Hypertension disorders are major factors responsible for morbidity and mortality in pregnancy and preeclampsia is the leading cause. The etio-pathology of PE is not known even after significant research done on it. Only thing which we can do is try to reduce the incidence and severity by predicting its occurrence. In our study we are trying to know the effect of serum calcium and serum magnesium on pre-eclampsia. Materials and Methods: Total 256 pregnant patients attending D.Y. Patil hospital were included in our study. They were divided into two groups namely normotensive and hypertensive. The diagnosis of Pre-eclampsia was made by standard protocol, inclusion and exclusion criteria were applied for selection of case after permission from ethical committee of the institution and consent of the patients. In them we estimated serum calcium and serum magnesium levels and the correlation of these levels was studied with the pre-eclampsia related factors. Results: Both groups comparable in terms of age, gravida, parity, high risk factors, BMI. The data was analysed by application of statistical test of significance. Conclusion: Our study shows that low levels of calcium and magnesium are found in serum of pre-eclampsia patients as compared to normotensive cases of the study population. Also since calcium deficiency plays role in aetiology of pre-eclampsia antenatal administration of Ca supplements was done and its effect was studied to find out whether it is useful in reducing the severity of PE. Keywords: Hypertensive disorder in pregnancy, Pre-eclampsia, S. calcium, S. magnesium.