Abstract
The current study was aimed to establish best anesthetic protocols in rabbit, for this purpose six clinically healthy male New Zealand White rabbits weighing 2±00 kg were procured. All rabbits received two anesthetic treatments with one week interval. Treatment: A Ketamine 35 mg/kg IM and Xylazine 5 mg/kg IM, Treatment B: Isoflurane (3 to 5 %) through facemask followed by Xylazine 5 mg/kg IM. Physiological parameters such as, heart rate, rectal temperature and respiratory rate were recorded before and after administration of anesthetics in all animals. Heart rate of all animals significantly (P 0.05) in both treatment groups. Induction of anesthesia was same in both treatment groups and was non-significant at (P>0.05). Isoflurane showed a significantly (P<0.05) longer duration of Anesthesia compared to Ketamine. Relaxation of muscle increased significantly (P<0.05) with Isoflurane compared to ketamine. Duration of analgesia and recovery from anesthesia was also found significant (P<0.05) with Isoflurane compared with ketamine. It was concluded that Isoflurane is the safe anesthetic agent for rabbits as an alternative of ketamine for longer duration of anesthesia and smooth recovery with enhanced analgesia. Keywords: Anesthesia; Isoflurane; Ketamine; Physiology; Rabbits http://dx.doi.org/10.19045/bspab.2019.80079
Highlights
IM, Treatment B: Isoflurane (3 to 5 %) through facemask followed by Xylazine 5 mg/kg IM
The data collected on the anesthetic effect of Isoflurane and Ketamine along with the preanesthetic Xylazine hydrochloride in a rabbit model are presented
Comparison of the two treatment showed that the heart rate after 5 minutes of induction increased (P
Summary
IM, Treatment B: Isoflurane (3 to 5 %) through facemask followed by Xylazine 5 mg/kg IM. It was concluded that Isoflurane is the safe anesthetic agent for rabbits as an alternative of ketamine for longer duration of anesthesia and smooth recovery with enhanced analgesia. The domestic rabbit (Oryctolagus research purpose, and especially in the fields cunicuclus) being docile is extensively used where laboratory techniques and in vivo as an animal model for a number of medicostudies for various pharmacological and Published by Bolan Society for Pure and Applied Biology toxicological effects are sought [1]. Anesthesia is the reversible loss of consciousness, which is induced with many types of anesthetic agents It is the art and choice of inducing analgesia, immobility and relaxed muscle tone for safe and smooth surgery and ease to the operator [2]. A variety of surgical procedures are performed using anesthesia including sedation for blood collection, as rabbits became stressed while handling sedation is required, Intravenous cannula placement, radiography [3], and other operative measures such as neutering, gastrotomy, cystotomy and fracture fixation [4]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
