Abstract
Objiective To compare the diagnostic value of 18F-fluorodeoxyglucose (FDG) PET/CT and 99Tcm-methylene diphosphonic acid (99Tcm-MDP) SPECT whole body bone scan in detecting of multiple myeloma bone disease (MBD). Methods The retrospective study enrolled 18 male and 11 female multipe myeloma (MM) patients, aged 39-81 years (mean, 60.14±10.41 years) and clinically diagnosed from April 2015 to May 2018 in Anqing hospital affiliated to Anhui medical university. 18F-FDG PET/CT and 99Tcm-MDP SPECT were performed two weeks apart, and χ2 test was used in comparing abnormal bone changes detected by 18F-FDG PET/CT and 99Tcm-MDP SPECT. Results 18F-FDG PET/CT and 99Tcm-MDP SPECT accurately diagnosed 28 and 21 MM patients, respectively. Eighteen patients were focal, one patient was diffuse, and nine patients were mixed on the18F-FDG PET/CT images. Twenty-one MM patients were found single, that is, multiple bones accumulated the agent abnormally on99Tcm-MDP SPECT images. The positive match rate of 18F-FDG PET/CT and 99Tcm-MDP SPECT were 96.6% (28/29) and 72.4% (21/29), respectively. The differences between the sensitivities of the two methods were significant. Conclusion The results indicate that 18F-FDG PET/CT is more sensitive than 99Tcm-MDP SPECT in detecting MBD in patients with MM and has a significant diagnostic value for bone marrow involvement and extramedullary disease. Key words: multiple myeloma bone disease; Positron emission tomography computed tomography; Tomography, emission-computed, single-photon; Fluorodeoxyglucose F18; Technetium Tc99m medronate
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