Comparative Study Between Virgin Coconut Oil and Omeprazole Drug on Ulcerative Colitis in Experimental Rats

Abstract

This study aims to identify the curative effect of virgin coconut oil on ulcerative colitis(UC),the present study was carried (24) adult albino male rats Sprague –Dawley strain weighting 180 ±10g were classified into four groups,(6 rats each) the first group rats were fed on basal diet only control negative(-ve) group and three rat groups were injured of ulcerative colitisby intra colonic administration of acetic acid 4% given rectally by single dose ( 1 ml/ rat ) and reclassified into control positive (+ve) group (fed on basal diet only), group treated with (20 mg/kg b.w) of omeprazole drug and group treated with (2 ml per/ rat) daily of virgin coconut oil . The results revealed that, the control (+ve) group showed a significant decrease in final weight(FW) ,weight gain(WG) feed efficiency ratio (FER), organs weight of heart, kidney, and liver , catalase (CAT), superoxide dismutase (SOD), glutathione reduced (GSH), Glutathione reductase (GSR),Glutathione peroxidase (GPx(, glutathione-S-transferees (GST) and significant increase in malondialdehyde (MDA) , hydrogen peroxide (H2O2), C-reactive protein (CRP), interleukin-6 (IL-K) and prostaglandin (PG2) compared with control (- ve) group. The virgin coconut oil group showed a significant increase in (FW),(WG),(FI),(FER),organ stomach,(CAT),(SOD),(GSH),(GSR (GPx), (GST) but significant decrease in (MDA),(H2O2),(CRP),(ILK), (PG2) compared with control (+ve) group . the study clearly showed that consumption virgin coconut oil has a role in treating rats with acetic acid-induced ulcerative colitis. It can be recommended that virgin coconut oil should be consumed daily to reduce the incidence of ulcerative colitis.