Abstract
Purpose: To compare the effects of raw hawthorn (RH) and charred hawthorn (CH) on functional dyspepsia (FD) and intestinal flora (IF).Methods: A rat model of FD was established through use of a chronic stimulator. Rat models were evaluated by the rat’s physical state, body weight, diet, and histopathological examination. After RH or CH administration, the digestive function of the rats was evaluated by determining gastric emptying and intestinal propulsion rate, diversity of intestinal flora.Results: RH and CH both improved gastric emptying and intestinal propulsion rate in FD group when compared to control group (p < 0.05). CH yielded higher treatment effectiveness than RH. Sixteen phyla of microbiomes were recognized from all samples. After FD model establishment, the relative abundance of Lactobacillus, Lachnospiraceae and Bacteroidales decreased compared to normal control rats. On the other hand, the relative abundance of Helicobacter and Bacteroides in the model control group increased compared to normal control. After RH and CH treatment, the relative abundance of all dysregulated phyla was restored to varying degrees, but the levels after CH treatment were similar to those of the normal control group.Conclusion: The relative abundance of intestinal flora of FD model rats is significantly different from that of rats in normal control group. Thus, RH and CH intervention improves digestive function, and the mechanisms may be related to adjustment of gut dysbacteriosis.Keywords: Raw Hawthorn, Charred Hawthorn, Functional dyspepsia, Intestinal flora
Highlights
Functional dyspepsia (FD) is one of the most prevalent functional diseases of the digestive tract, and the incidence of FD is increasing with each passing year
This paper studied the differences between the effects of raw hawthorn (RH) and charred hawthorn (CH) on the digestive system and intestinal flora of FD rats
An FD model in rats was developed through of a chronic stimulator as described in as described in the Experimental section After 21 days rats in the SG presented with losses in body weight, dull and messy hair, slow reaction times, sluggish spirits, pasty and loose stools, poor appetites, and lassitude
Summary
Functional dyspepsia (FD) is one of the most prevalent functional diseases of the digestive tract, and the incidence of FD is increasing with each passing year. FD is characterized by an extended course, tending towards recrudescence of symptoms that include epigastric pain and burning, feeling bloated after a meal, early satiation, distension in the epigastric region, and nausea and vomiting in Hawthorn refers to the ripe fruit of Crataegus pinnatifida Bge. var. Major N.E.Br. or Crataegus pinnatifida Bge, belonging to the Rosaceae family of plants. In addition to being consumed as a food, hawthorn is a traditional Chinese herbal medicine that has been used for over a thousand years to treat dyspepsia, cardiodynia, hernia, and postpartum blood stasis. Processing (pao zhi) is an integral step before clinical application of Traditional Chinese Medicine (TCM). The mechanism behind the efficacy of hawthorn it cannot, as yet, be fully explained by any theory
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