Abstract
A total of 100 one-day-old healthy broiler chicks were used to study the effects of lincomycin and bacitracin on some hematobiochemical and immunological parameters. Chicks were divided into four equal groups, 25 each. The first group was kept as control; the 2nd group was received 0.5 g of lincomycin per liter; the 3rd group was received 100 mg bacitracin per liter and the 4th group was administered both lincomycin and bacitracin, each at the above-mentioned dose. Drugs were given in drinking water for 5 successive days from 20th to 25th day of age. Bodyweight was recorded at the beginning of the experiment and at 1st-day post administration where body performance was recorded. One day post administration, blood samples were collected for estimation of hematobiochemical and immunological alterations. The obtained results revealed that broiler chicks administered lincomycin or bacitracin or both revealed a marked increase in bodyweight, weight gain, phagocytic activity, phagocytic index, erythrocytic count, hemoglobin level, packed cell volume, total leukocytic count, serum total protein, albumin, total globulin, α, β and γ globulin. Furthermore, a significant elevation in malondialdehyde associated with a marked reduction in albumin-globulin ratio, serum total lipid, cholesterol and triglyceride and a significant decrease in catalase and superoxide dismutase, were recorded, compared with the control group. In conclusion, lincomycin and bacitracin either alone or in combination have positive impacts on growth performance, immunological and hematobiochemical parameters of broiler chickens. So, it is recommended to use both drugs as growth promoters in broiler chickens.  Â
Highlights
Poultry is considered as a good source of animal protein with a high biological value for human consumption all over the world (Gilmour et al 2004)
Healthy broiler chickens received bacitracin and lincomycin either alone or together showed non-significant elevation on body weight and weight gain but improved feed conversion rate throughout the experimental period when compared with the control group (Table 1)
Oral giving of bacitracin or lincomycin in the tested doses displayed nonsignificant reductions in serum total lipid, cholesterol and triglyceride in healthy broiler chickens when compared with control broilers (Table 4)
Summary
Poultry is considered as a good source of animal protein with a high biological value for human consumption all over the world (Gilmour et al 2004). Lincomycin is a naturally occurring lincosamide antibiotic obtained as a fermentation product of Streptomyces lincolnensis. It has a spectrum of activity against Gram-positive bacteria and most anaerobes (Greenwood 2010). Bacitracin is used for the treatment and control of many infections in broiler chickens as Clostridium perfringens infection (Rukmini et al 2015) which is one of the most economically important gut diseases in broiler chickens with a high mortality rate (Aboubakr & Elbadawy 2017). The present study was conducted using a large number of chickens to determine the effects of lincomycin and bacitracin on some hematobiochemical and immunological parameters in healthy broiler chickens
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