Abstract
<p><em>Pterocarpus marsupium</em> is widely used as ‘Rasayana’ in ayurvedic system for curing several medical ailments. In view of this, petroleum ether and chloroform extracts of <em>Pterocarpus marsupium</em> bark was scrutinized to unfold free radical scavenging by measuring their capability for scavenging DPPH radical, ABTS, phosphomolybdenum assay as well as reducing power capacity assessment and anti- inflammatory activity by inhibition of protein denaturation. Additionally, RBC’S were also used to explore the potentiality of <em>Pterocarpus marsupium </em>different extracts to shield RBC in oxidative stress condition. Chloroform extract showed an effective pharmacological activity in all assays when compared with petroleum ether extract and their respective standards. This reveals the use of <em>Pterocarpus marsupium </em>as a potent source of antioxidant, anti-inflammatory, anti-haemolytic agent and would provide an ample opportunity for further investigation. Isolation of active compounds from this plant responsible for producing such bioactivities is under process.</p>
Highlights
Free radicals are regarded as fundamental biochemistry which forms an important part of aerobic metabolism
Scientific research on medicinal plants has implied antioxidant presence such as tannins, phenolics, flavonoids and its consumption reduced morbidity, mortality caused from degenerative disorders [5]
Substantial attention has been focused towards credentials of plants with antioxidant, antiinflammatory and anti-haemolytic abilities
Summary
Free radicals are regarded as fundamental biochemistry which forms an important part of aerobic metabolism They are important for maintaining normal physiological functions such as signaling molecules, regulation of signal transduction and gene expression, activation of receptor and nuclear transduction [1]. Imbalance of this metabolism due to metabolic and other environmental factors generates excessive ROS that give rise to oxidative stress. This results in the damage of various biomolecules like DNA, lipids and proteins which is affiliated with several illnesses like cancer, neurodegenerative diseases, atherosclerosis, infertility, hepatitis and rheumatoid arthritis [2]. Different pieces of bark are used as antacid, anti-diarrheal, for DOI:10.5138/09750185.2021
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