Comparative Pharmacokinetics/Pharmacodynamic Modeling on Three Brands of 10% Enrofloxacin Oral Formulations in Broiler Chickens

Abstract

A comparative plasma pharmacokinetics/Pharmacodynamic modeling of enrofloxacin following administration of three brands of 10% enrofloxacin was studied in healthy broiler chickens using a randomized and parallel design. Pre-treatment and post-treatment samples were obtained from brachial or right jugular veins after having administered 20 mg/kg b.w of enrofloxacin at 0, 0.5, 1, 2, 3, 4, 6, 8, 10, 12 and 24 h. Plasma samples were analyzed for enrofloxacin concentration by a simple agar disk diffusion microbiological assay. Selected pharmacokinetics parameters were calculated using a non-compartmental model. There was a significant difference in the plasma concentration-time and pharmacokinetics profiles (p<0.05) of the three brands. But the plasma concentrations of enrofloxacin exceeded the MIC for most 90 pathogenicbacterial organisms in poultry in all the groups. The PK/PD integration (C /MIC ) values, 16.67, max 90 15.17 and 10.5 h were obtained in animals administered conflox -vet, kenflox and pulmotryl formulations ® ® ® respectively. This correlates with high efficacy and reduced chances for the development of resistant pathogenic bacterial organisms following oral administration of these brands of enrofloxacin oral formulations in broiler chickens.