Abstract
The results of a prospective longitudinal controlled study comparing some metabolic effects of a low-dose levonorgestrel-ethinyl oestradiol combined oral contraceptive (Microgynon ® 30), a desogestrel-ethinyl oestradiol-containing pill (Marvelon ®) and a levonorgestrel-ethinyl oestradiol triphasic preparation (Triquilar ®) after one year of treatment in ethnic Chinese women are presented. Serum cholesterol levels are similar for the three pills at 6 and 12 months of treatment. Marvelon ® and Triquilar ® users showed rises in triglyceride levels while Microgynon ® 30 users had no change after one year of treatment. Lipoprotein fractions showed favourable changes in Triquilar ® and Marvelon ® users with significant rise in HDL fractions at 6 and 12 months; Microgynon ® 30 users had equivocal changes in HDL fractions. Carbohydrate metabolism as reflected by glucose tolerance showed deterioration with all 3 pills, being least with Microgynon ® 30 and greatest with Marvelon ®at 12 months
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