Abstract
Distribution and elimination of benz( a)anthracene (B(a)A), chrysene (Ch), and triphenylene (Tr) were compared after oral administration of the single compounds to 7–8-week-old female rats. These fourring isomers were chosen because of their different carcinogenicity. The compounds have high affinity for lipid-rich tissues such as brain, mammary and parametrial adipose tissue. The relative availability of these compounds in the tissues examined decreased in the order Tr>B(a)A>Ch, but fecal elimination diminished in the opposite order Ch>B(a)A>Tr. Availability and fecal elimination of single polycyclic aromatic hydrocarbons (PAH) were influenced by the dose and concentration of PAH in the vehicle.
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