Comparative evaluation of atorvastatin and simvastatin on critical fusion frequency in healthy volunteers

Abstract

Background: Atorvastatin and simvastatin are the most frequently prescribed among statins to reduce high lipid levels. Statins are reported to alter cognitive functions. However, the results are equivocal as numbers of studies have shown improvement in the cognitive function, while others have documented impairment. Aims and Objectives: The present study was undertaken to compare the effects of atorvastatin and simvastatin on critical flicker fusion frequency (CFFF) which is a most sensitive indicator of cortical arousal. Hence, that outcome of the trial provides evidence of the alterations in cognition in unambiguous terms. Materials and Methods: A single-dose, open-label, crossover study was conducted in 15 healthy volunteers. They were familiarized on CFFF test apparatus till they attained plateau level in their values. Predrug score was recorded before giving test drug on the trial day. Volunteers were then given oral single dose of either of drug (atorvastatin 10 mg or simvastatin 10 mg) and then crossed over with 10 days washout period between both treatments. In each arm, volunteers were followed up to 6 h for the postdrug score. Results: Both atorvastatin and simvastatin decreased the CFFF significantly during the entire study period (P = 0.0001) from their respective predrug values. On comparison, both these drugs produced identical CFFF decline (P > 0.05). Conclusion: Result of current study highlights the impairment of CFFF with both of these drugs in similar manner in healthy volunteers. However, the trials with long-term treatment in patients are advised to clearly define their role in cognitive function.