Abstract
Objective. Comparative estimation of diagnostic informativity of a fine-needle aspiration biopsy (FNAB) and pathohistological investigation of nodal thyroidal tumors.
 Маterials and methods. Retrospective analysis of the FNAB and the thyroidal pathohistology results was conducted in 171 patients before and after thyroidectomy, performed for nodal thyroidal tumors.
 Results. In accordance to the FNAB results a benign thyroidal affection was revealed in 131 (76.6%) patients and a malignant one - in 12 (7%). The method sensitivity has constituted 83.3%, and specificity - 98,5%. In 28 (16.4%) patients the FNAB results were uncertain. In 4 (14.3%) of 28 patients while further pathohistological investigation doing, a malignant affection of a thyroid gland was revealed (follicular cancer - in 1, papillary - in 1, follicular form of papillary cancer - in 1, Hurthle-cellular and papillary cancer - in 1). In 24 (85.7%) of 28 patients a benign thyroidal affection was revealed. In this group the FNAB sensitivity have constituted 65-99%, specificity - 98.5%. As a result of pathohistological investigation a benign thyroidal affection in 153 (89.5%) of 171 patients and malignant - in 18 (10.5%) were revealed.
 Conclusion. In preoperative diagnosis of nodal thyroidal tumors the uncertain FNAB results rate in preoperative diagnosis of nodal thyroid tumors, in accordance to our data, have constituted 16.4%, what restricts possibilities of this method in verification of malignant thyroidal affections. That is why the operation must not be indicated, basing on the FNAB data only, and molecular-genetic markers ought to be analyzed in this group of patients.
Highlights
Retrospective analysis of the fine–needle aspiration biopsy (FNAB) and the thyroidal pathohistology results was conducted in 171 patients before and after thyroidectomy, performed for nodal thyroidal tumors
In accordance to the FNAB results a benign thyroidal affection was revealed in 131 (76.6%) patients and a malignant one – in 12 (7%)
That is why the operation must not be indicated, basing on the FNAB data only, and molecular–genetic markers ought to be analyzed in this group of patients
Summary
Проведен ретроспективный анализ результатов ТАБ и патоморфологического исследования ЩЖ у 171 больного до и после тиреоидэктомии по поводу узловых образований ЩЖ. По результатам ТАБ доброкачественное поражение ЩЖ выявлено у 131 (76,6%) больного, злокачественное – у 12 (7%). Чувствительность метода составила 83,3%, специфичность – 98,5%. У 28 (16,4%) больных результаты ТАБ были сомнительны. У 4 (14,3%) из 28 больных впоследствии при патоморфологическом исследовании было выявлено злокачественное поражение ЩЖ (фолликулярный рак – у 1, папиллярный – у 1, фолликулярная форма папиллярного рака – у 1, Гюртле–клеточный и папиллярный рак – у 1). В этой группе чувствительность ТАБ составила 65–99%, специфичность – 98,5%. В результате патоморфологического исследования доброкачественное поражение ЩЖ выявлено у 153 (89,5%) из 171 больного, злокачественное – у 18 (10,5%). В дооперационной диагностике узловых образований ЩЖ частота сомнительных результатов ТАБ, по нашим данным, составила 16,4%, что ограничивает возможности данного метода для верификации злокачественного поражения ЩЖ. Ключевые слова: щитовидная железа; узловые образования; тонкоигольная аспирационная биопсия; патоморфологическое исследование
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
