Abstract
Introduction Pediatric bronchopneumonia is one of the common respiratory diseases in pediatrics. Chinese herbal injections (CHIs) are widely used to treat pediatric bronchopneumonia. In this study, we examined the efficacy of CHIs in the treatment of pediatric bronchopneumonia using a network meta-analysis (NMA). Methods Randomized controlled trials (RCTs) of CHIs combined western medicine (WM) versus WM were searched from electronic databases. WinBUGS 1.4.3 and Stata 13.0 were adopted to compute calculations and prepare graphs, respectively. Results 168 RCTs with 21917 patients were included. The results revealed that Xixinnao injection (XXN) + WM had the most probability to be the best intervention in the four aspects of rate of clinical efficacy, antipyretic time, cough disappearance time, and lung shadow disappearance time. While as to lung shadow disappearance time, asthma disappearance time, and hospitalization time, Yanhuning injection (YHN) + WM could be the best intervention. The safety of CHIs needs to be further assessed. Conclusions Based on this NMA, XXN + WM and YHN + WM were potential optimal therapies in pediatric bronchopneumonia, and their safety should be strictly monitored.
Highlights
Pediatric bronchopneumonia is one of the common respiratory diseases in pediatrics
No statistically significant difference was observed between the other interventions
According to results of rank probability based on surface under the cumulative ranking curve (SUCRA) (Figure 4; Table 2), XXN + western medicine (WM) was shown to be the best intervention to improve the rates of clinical efficacy (RCE), followed by Xiyanping injection (XYP) + WM and Yanhuning injection (YHN) + WM
Summary
Pediatric bronchopneumonia is one of the common respiratory diseases in pediatrics. Chinese herbal injections (CHIs) are widely used to treat pediatric bronchopneumonia. E results revealed that Xixinnao injection (XXN) + WM had the most probability to be the best intervention in the four aspects of rate of clinical efficacy, antipyretic time, cough disappearance time, and lung shadow disappearance time. One of the common respiratory diseases in pediatrics, refers to an inflammatory reaction that is mainly caused by viral, bacterial, or mycoplasma pneumoniae and other pathogenic microorganisms invading the body through the respiratory tract and clinically resulting in cough, fever, dyspnea, lung rale, and so on [1,2,3]. A combination between Chinese herbal injections (CHIs) and western medicine (WM) treatment has already achieved some results in treatment of pediatric bronchopneumonia [8,9,10], but since various CHIs can be chosen, the one with best efficacy is still to be explored
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