Comparative analysis of the methods for the estimation of the biological age

Abstract

The present article was designed to report the results of comparative analysis of the methods for the estimation of the biological age based on the measurement of a number of anthropometric and functional characteristics in the relatively healthy persons at the age varying from 30 years to 75 years. The study involved 277 individuals (143 women and 134 men). All the patients underwent clinical, biochemical, hormonal and instrumental examination. The following two methods were used to determine the biological age of the participants of the study: the ontogenetic anthropometrical method (L.M. Belozerova, 1999) and the Kiev method (V.P. Voytenko, 1984). These mathematical models are based on a specific set of calculation techniques for each anthropometric and instrumental parameter and approximately equally reflect the mismatch between the calendar and biological age; however, they are different in the degree of correlation with the disturbances of metabolism, enzymatic maintenance of metabolic processes, and other parameters. By way of example, the method of L.M. Belozerova for the calculation of the anthropometric biological age largely correlates with the insulin resistance index, blood concentrations of aldosterone, triglycerides and glucose, whereas the results obtained by the method of V.P. Voytenko show stronger correlation with the activity of alkaline phosphatase, the ceruloplasmin level and self-estimation of the patients' health.