Abstract
Degradation processes occurring in linear polyurethanes differing in their chemical composition (polydiethylene glycol succinate with M = 750, polydiethylene glycol adipate with M = 1500 and 800, and hexamethylenediisocyanate, using ethylene glycol as the chain lengthening agent) have been investigated in physiological solution and in vivo. It is shown that polyurethanes containing a large amount of readily hydrolizing ester groups are more prone to degradation than those with a low ester group content. The hydrolysis of ester groups is the main degradation reaction. Accordingly the hydrolysis constants were calculated for polymer A-10 (the most rapidly degrading polymer among those under study) after viscosimetric determination of the molecular weights. The constants for A-10 were found to be 6·6 × 10 −3 day −1 ( in vivo) and 4·15 × 10 −3 day −1 (in physiological solution).
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