Abstract
a peer-reviewed, open access online international journal which publishes original research papers. The journal welcomes submission from scholars and experts for possible publication from all over the world. The scope of the journal includes: Pharmaceutical research, chemistry and biochemistry of naturally occurring compounds, biological evaluation of crude extracts, ethnomedicine, traditional and complementary medicine, ethnopharmacology, biomedical research, Biotechnology, Evaluation of natural substances of land and sea and of plants, microbes and animals, pharmacognosy, bioavailability, clinical, pharmacological, toxicological studies and pharmacokinetics of phytochemicals, Isolation and characterization of compounds, structure elucidation, synthesis and experimental biosynthesis of natural Product as well as developments of methods in these areas are welcomed in the journal.
Highlights
Pegagan (Centella asiatica) is one of the plants that are found wild in Indonesia
Nanoparticles improve the pharmacokinetic properties of the constituents and reduce the irritating effect of active substances on the gastrointestinal tract.[2,7]
Nanoparticles penetration to the human body can increase therapeutic efficacy, bioavailability and surface area resulting in a faster dissolution of the active agent in an aqueous environment.[8,10]
Summary
Pegagan (Centella asiatica) is one of the plants that are found wild in Indonesia. C. asiatica contains high flavonoid and triterpenoid compounds so that this plant is considered to have antioxidant and neuroprotective activity.[1]. Previous studies found that the method uses ionic interactions between positively charged amino chitosan groups and polyanion in the form of negatively charged sodium tripolyphosphate (STPP) and the results will reduce material size to nano size.[3,4] The phytochemical properties of pegagan extract (PE) or pegagan nanoparticle form (PN) have not been completely confirmed yet even though C. asiatica is proven to have great potential as herbal medication. The aims of this study were to perform comparative analysis of phytochemical and antioxidant activity of PE and PN, as well as to predict compounds having antioxidant activity through metabolite profiling. It has been known that LC-MS is a technique used for metabolite profiling which has improved performance of chromatographic resolution, speed and sensitivity analysis. The technique is proven to have less time in profiling analysis and reduce solvent consumption.[5]
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