Abstract
Flurbiprofen was incorporated in different carriers like sodium alginate gel, calcium alginate microspheres, gelatin nanoparticles and complex with betacyclodextrin and incorporated in polyethylene glycol bases. Pharmacodynamic and bioavailability studies were carried out in male rats. It was found that drug incorporated in sodium alginate gel and drug complexed with betacyclodextrin were found to be suitable for designing tranadermal preparations since they resulted in better therapeutic efficacy.
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