Abstract
Commentary: Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.
Highlights
It is well-known that high levels of Synaptic vesicle 2C proteins (SV2C) were found primarily in old brain regions like pallidum, substantia nigra, midbrain, brainstem, and olfactory bulb
Within the dopaminergic neurons in substantia nigra pars compacta and the ventral tegmental area, SV2C was densely expressed
Another group predicted the Parkinson’s disease (PD) patients’ sensitivity to LDOPA due to variation within the SV2c gene (Altmann et al, 2016). These findings proposed that SV2C may play critical functions in the basal ganglia, further research work is needed to establish the hypothesis like SV2C mediated chemical effects of nicotine, or to PD
Summary
It is well-known that high levels of Synaptic vesicle 2C proteins (SV2C) were found primarily in old brain regions like pallidum, substantia nigra, midbrain, brainstem, and olfactory bulb. A commentary on Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease by Dunn, A. (SV2C) modulates dopamine release and is disrupted in Parkinson disease.
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