Abstract
Commentary: Dopamine-Dependent Early Synaptic and Motor Dysfunctions Induced by α-Synuclein in the Nigrostriatal Circuit.
Highlights
Edited by: Cong Liu, University of Chinese Academy of Sciences, ChinaReviewed by: Evangelia Emmanouilidou, National and Kapodistrian University of Athens, Greece Shotaro Shimonaka, Juntendo University, JapanReceived: 06 October 2021 Accepted: 01 November 2021 Published: 29 November 2021Citation: Zhang J, Liu H and Jiang H (2021) Commentary: Dopamine-DependentEarly Synaptic and Motor Dysfunctions Induced by α-Synuclein in the Nigrostriatal Circuit
The results of this study found that the retrograde translocation of labeled phosphorylated-alphasynuclein (p-α-syn) occurred in the substantia nigra pars compacta (SNpc) region at both 6 and 12 weeks after striatal injection and that DA neuron activity was altered in a time-dependent manner
It is extremely intriguing that this study explores, for the first time, the role of impairment of the α-syn-dependent dopaminergic nigrostriatal system in the onset and development of deficits in striatal synaptic properties and plasticity, which are associated with autonomic motor dysfunction
Summary
Synaptic and Motor Dysfunctions Induced by α-Synuclein in the Nigrostriatal Circuit. In the early stages of PD, α-syn accumulation impairs synaptic vesicle fusion and aggregation (Longhena et al, 2017), affecting neurotransmitter release and leading to nigrostriatal neuronal death (Imbriani et al, 2018).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
