Abstract
Axonal transport is essential for the development, function, and survival of neurons, and impaired axonal transport has been implicated in many neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease
Highlights
J Neurol Neuromedicine (2016) 1(8): 19-21. Jlp ablations for this study[7], and these mice might serve as a useful animal model for studying the molecular mechanisms of neurodegenerative disorders
Histological analysis of 24-week-old mice revealed the specific loss of Purkinje cells (PCs) and the presence of swollen PC axons in mice with a conditional double KO of Jsap[1] and Jlp (Jsap1:Jlp cDKO), but not in control mice or those with a single Jsap[1] or Jlp cKO
The authors found that the PC counts were comparable in control and Jsap1:Jlp cDKO mice at 8 weeks of age; after this age, the PC counts decreased in cDKO mice compared to control mice
Summary
Jlp ablations for this study[7], and these mice might serve as a useful animal model for studying the molecular mechanisms of neurodegenerative disorders. Axonal transport is a complex and highly regulated process that is essential for neuronal development, function, and survival, and defective axonal transport has been implicated in many neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease[1,2].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
