Abstract
Polychaetes have been used as useful model organisms for environmental pollution monitoring in aquatic sediments. Here, we investigated the combined effect of copper (50, 100 and 200 μg/L) and cadmium (50 μg/L) on the expression of antioxidant enzymecoding genes (seven GST isoforms, Mn-SOD and Cu/Zn-SOD) in the marine polychaete Perinereis nuntia by quantitative real-time RT-PCR. As a result, SOD genes, especially Cu/Zn-SOD significantly increased up to 48 h after exposure to a mixture of Cu and Cd in a time and concentration-dependent manner more than in 50 μg/L Cd alone exposure. Similar expression patterns were observed in most GST isoforms. In particular, GST-omega and GST-sigma gene expression were highly upregulated in response to a combined stress of Cd and Cu. These findings suggest that such genes would be useful as a potential molecular biomarker for monitoring of combined environmental pollutions in aquatic ecosystem.
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