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Abstract
Diabetes is a metabolic disorder that causes vascular complications. As vitamin C and E is known for its beneficial effects on blood sugar, serum lipids and glycated haemoglobin (HbA1c). In the present study, we assess the combined effect of vitamin C and E on blood sugar (FBS), serum creatinine (SC), total cholesterol (TC), low and high density lipoprotein (LDL, HDL), and glycated haemoglobin (HbAIc) in type 2 diabetes mellitus patients. A total of 50 patients with type 2 diabetes referred to Rama Hospital (NCR), India, were included in the study. They received 500 mg daily twice of both vitamin C and E for 4 months. Fasting blood sugar (FBS), serum creatinine (SC), total cholesterol (TC), low and high density lipoprotein (LDL, HDL), and HbAIc were measured before and after vitamin C and E consumption and the results were analyzed. A significant decrease in FBS, TC level and non-significant decrease in SC, LDL, and HbA1c level was seen in the patients supplemented with 500 mg of both vitamin C and E twice in a day for 4 months. Results indicate that daily consumption of 500 mg of vitamin C and E for 4 months may be beneficial for decreasing the FBS, TC, SC, LDL, and HbA1c and slight raise in HDL and calcium level in patients with type II diabetes and thus reducing the risk of complications.
Highlights
Pandit and Pandey [1]; Awasthi et al [2] proposed that diabetes mellitus is a multi-factorial metabolic disorder and forthcoming epidemic all over the globe that caused due to ineffective secretion of insulin
Afkhami-Ardekani and Shojaoddiny-Ardekani [29] proposed significant decrease in Fasting blood sugar (FBS), TG, low density lipoprotein (LDL), HbA1c and serum insulin was observed in diabetic patients supplemented with 1000 mg vitamin C
Forghani et al [30] proposed significant decrease in serum HbA1c and LDL levels observed in diabetic patients supplemented with 1000 mg/day of vitamin C for 6 weeks but according to Bishop et al [31] supplementation only 500 mg/day vitamin C resulted in no significant changes observed in FBS, total cholesterol (TC), TG and HbA1c level
Summary
Pandit and Pandey [1]; Awasthi et al [2] proposed that diabetes mellitus is a multi-factorial metabolic disorder and forthcoming epidemic all over the globe that caused due to ineffective secretion of insulin. Afkhami-Ardekani et al [9] and Dakhale et al [10] proposed that, vitamin C and glucose show structural similarities, and they are effective in prevention of non-enzymatic glycosylation of proteins. Chambial et al [11] proposed that, vitamin C is an antioxidant that protects body from damage caused by free radical and used as therapeutic agent for diseases and disorders. Simom [11] proposed that, vitamin C acts as regulator of catabolism of cholesterol and Ness et al [13] proposed beneficial effects on lipids regulation
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