Abstract
Chronic Obstructive Pulmonary Disease (COPD) is a worldwide health problem associated with high morbidity and mortality, especially in elderly patients. Aging functions include mitochondrial dysfunction, cell-to-cell information exchange, protein homeostasis and extracellular matrix dysregulation, which are closely related to chronic inflammatory response and oxidation-antioxidant imbalance in the pathogenesis of COPD. COPD displays distinct inflammaging features, including increased cellular senescence and oxidative stress, stem cell exhaustion, alterations in the extracellular matrix, reduced levels of endogenous anti-inflammaging molecules, and reduced autophagy. Given that COPD and inflammaging share similar general features, it is very important to identify the specific mechanisms of inflammaging, which involve oxidative stress, inflammation and lung mesenchymal stem cell function in the development of COPD, especially in elderly COPD patients. In this review, we highlight the studies relevant to COPD progression, and focus on mechanisms associated with inflammaging.
Highlights
Chronic Obstructive Pulmonary Disease (COPD) is a worldwide health problem associated with high morbidity and mortality, especially in elderly patients
Chronic Obstructive Pulmonary Disease (COPD) is a common public health problem associated with high morbidity and mortality
Aging functions include mitochondrial dysfunction, cell-to-cell information exchange, protein homeostasis and extracellular matrix dysregulation, all of which are closely associated with chronic inflammatory response and oxidant-antioxidant imbalance in the pathogenesis of COPD
Summary
Chronic Obstructive Pulmonary Disease (COPD) is a common public health problem associated with high morbidity and mortality. Aging functions include mitochondrial dysfunction, cell-to-cell information exchange, protein homeostasis and extracellular matrix dysregulation, all of which are closely associated with chronic inflammatory response and oxidant-antioxidant imbalance in the pathogenesis of COPD. Since COPD and inflammaging share similar characteristics, it is imperative for a better understanding of the development of COPD to identify and elucidate the mechanisms of oxidative stress, inflammaging and lung mesenchymal stem cell function. This is especially important in elderly COPD patients. The aim was to assess our knowledge of the specific mechanisms operating in COPD that are responsible for oxidative stress, inflammaging and abnormal lung mesenchymal stem cell function, and their interactions.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
