Abstract
G antigen is present on almost all D+ or C+ cells and absent from virtually all red cells which lack D and C antigens. Anti-G antibody serologically mimics a combination of Anti-C and Anti D. The challenge of anti G in the antenatal setting is to identify whether Anti D is present or not. If anti-D is absent, the female can still get immunized against D antigen, so she will be a candidate to receive Rh immune globulin prophylactic therapy. If anti D is present, the presentation of HDFN may be more severe. So it is important to know if the antibody is really anti G or a combination of anti D and anti C with or without anti G. We here report a case of HDFN which on advanced immunohematolgy work up revealed a combination of Anti G and anti D in mother's serum. Anti-D was present in the mother despite immunoprophylaxis, which indicate inadequate dosage.
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