Abstract
Wallen et al. employed a colostrum exosome-based nanoparticle delivery system, exosome-PEI matrix (EPM), to help develop a flexible, testable therapeutic model system. Based on this system, plasmid DNA and small interfering RNA (siRNA) were delivered into in vitro cell lines and in vivo. Three essential severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins—spike glycoprotein, nucleocapsid, and replicase—were expressed to mimic the expression of the viral genome; certain siRNAs were found to silence their matched proteins with 80%–95% efficiency, indicating their therapeutic potential.
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