Abstract
The entomopathogenic fungus Polycephalomyces nipponicus is known to have activity against human pathogenic bacteria and the malaria pathogen; however, information about its genetic variation is limited. In this study, cicada nymphs infected with entomopathogenic fungi were collected from various locations in the northeast of Thailand. Internal transcribed spacer sequencing was used to identify the fungal pathogen P. nipponicus. A total of 36 isolates of P. nipponicus from 6 provinces were investigated for variations in fungal morphology, nucleoside analog content, and genetics. The results showed that colony morphology varied depending on the strain of the tested fungi, without influence from its geographic origin. A similar finding was observed with regard to the production of nucleoside analog content. Interestingly, the important bioactive compound adenosine was detected in the mycelial extract of all 36 isolates. This indicates that P. nipponicus could possibly be used as a source of potential therapeutic bioactive compounds. In addition, random amplified polymorphic DNA analysis, as supported by the Nei Index and Shannon Index values, showed high genetic variation within and between the populations. These findings represent what is, to our knowledge, the first information on the colony morphology, adenosine analog profile, and genetic variation of P. nipponicus.
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