Abstract
In this study, colonic manometry studies of the patients with repaired anorectal malformations (ARM) were compared with those of patients with severe colonic dismotility due to chronic constipation (CC) and acute pseudo-obstruction (PSO). The patients with repaired ARM were accepted as group #1 (n=10). The patients with CC and acute PSO composed group #2 (n=10). Eight-channel water perfused catheter was inserted into the colon under sedation. Colonic activity was recorded in three phases including fasting, after meal and after bisacodyl installation. The results were assessed by Pearson χ2 test, P<.05 was considered statistically significant. Mean age was 9.6 and 12.1 in groups #1 and #2, respectively. Ninety-five per cent of all patients had propagated contractions (PCs) and 20% and 40% of the patients in group #1 had PCs during fasting and after meal, respectively. These contractions were seen 30% and 70% of the patients in group #2, but no statistical difference was found between the groups. PCs after bisacodyl were observed 90% and 40% of the patients in groups #1 and #2, respectively, and this difference was statistically significant (P=.019). In this study, the prominent difference between the groups was found in response to intraluminal stimulation. This finding may indicate that the colon of the patients with ARM has more capacity to develop PCs by peripheral stimuli and more regular enteric nervous integrity.
Highlights
Abstract ly In this study, colonic manometry studies of n the patients with repaired anorectal malformations (ARM) were compared with those of o patients with severe colonic dismotility due to e chronic constipation (CC) and acute pseudoobstruction (PSO)
The prominent difference between the groups was found in response to intraluminal stimulation. This motor activity of the colon in patients with ARM and to compare them with the results obtained from the children with severe colonic dismotility
Colonic manometry was performed according to previously reported protocol.[1]
Summary
Contributions: BD designed the study and project, evaluated the results and wrote the manuscript; SS performed colonoscopy; OE performed colonoscopy and helped to preparation of the manuscript; CK helped colonoscopy studie; IO helped to preparation of the manuscript; KS con-. Ninety-five per cent of all patients had propagated contractions (PCs) and 20% and o 40% of the patients in group #1 had PCs during -c fasting and after meal, respectively. These contractions were seen 30% and 70% of the n patients in group #2, but no statistical differo ence was found between the groups. The prominent difference between the groups was found in response to intraluminal stimulation This motor activity of the colon in patients with ARM and to compare them with the results obtained from the children with severe colonic dismotility
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