Abstract
Group motility of endothelial cells is studied in vivo using a recently developed TIE1-YFP transgenic quail line and in cell cultures. Statistical analysis of motility data show that endothelial cell movements are guided by intercellular contacts, both during vasculogenic sprout formation and within the walls of large early vessels like the dorsal aortae and vitelline arteries. This coordinated, but unoriented cell motility turns into an organized migration towards the heart after the onset of circulation. To interpret our empirical findings, we propose a computational model of endothelial cell motility which includes a positive feedback between cell polarity and cytoskeletal expansion, as well as response to micromechanical cues from the environment.
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