Abstract
A DNA bank has been created from the Millennium Cohort Study (MCS) saliva samples. A total of 23,336 samples are available, from 9,259 cohort members (4,630 males and 4,629 females), 8,898 mothers and 5,179 fathers. There are 4,533 mother, child, father 'triads'. This paper describes the collection of the saliva samples from cohort members and their biological parents in the MCS. It analyses response rates and predictors of response, and details the DNA extraction, genotyping and imputation procedures performed on the data.
Highlights
The Millennium Cohort Study (MCS) is a large and nationally representative birth cohort study following the lives of children born across the UK around the turn of the millennium (Connelly and Platt, 2014; Joshi and Fitzsimons, 2016)
This paper describes the collection of the saliva samples from cohort members and their biological parents in the MCS
It describes the collection of saliva samples in the Millennium Cohort Study, from cohort members and their resident biological parents
Summary
The Millennium Cohort Study (MCS) is a large and nationally representative birth cohort study following the lives of children born across the UK around the turn of the millennium (Connelly and Platt, 2014; Joshi and Fitzsimons, 2016). The addition of genetic information to this rich, longitudinal data resource will enable discovery of genome-wide association study (GWAS) analyses based on study focus traits, trajectories and familial phenotypes. We expect this resource to trigger a range of studies into how genetic and environmental factors shape human development across the life course. The paper proceeds as follows: background; an overview of the fieldwork collection; a discussion of the DNA extraction process; response rates; genotyping, quality control and imputation; illustration of the resource’s self-described ethnic diversity and continental genetic ancestry; and accessing the data
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