Abstract
In this work, a blend of collagen, physiologically clotted fibrin (PCF), and silver nanoparticles (AgNPs) is used to develop a nanobioscaffold (NBS), for their possible application in wound dressing materials. The prepared NBS were evaluated using physicochemical, mechanical, and antibacterial properties. The NBS cell viability was demonstrated in a biocompatibility study using the human keratinocyte cell line (HaCaT). The results demonstrated that the NBS had excellent tensile strength (22.15 ± 0.05 MPa), elongation at break (13.32 ± 0.09%), and water absorption (97.51 ± 0.08). The in-vitro study demonstrated its biocompatible nature. NBS exhibited significant antibacterial activity against the Gram-negative and Gram-positive bacteria. The NBS with required mechanical strength, antibacterial activity, and biocompatibility may be tested as a wound material in rats after getting the necessary approval.
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