Abstract
Hydroxyapatite (HA) is widely used as bone substitute material in repairing bone defects and injuries. However, the high brittleness and low fatigue strength of HA make it difficult to satisfy the long-term service requirements of implants. In general, the mechanical properties of ceramics can be improved by sintering which usually operated above 1000 °C. The high temperature not only brings huge energy consumption and environmental pollution, but also loss the surface-active sites on HA, which greatly limits the biological functions of the material, such as drug loading and degradation. A method that can achieve the densification of HA at a lower temperature is particularly important to improve mechanical and biological properties. In this work, a promising drug-loaded HA-polylactic acid (HA-PLA) composite with high densification and mechanical properties was prepared by cold sintering process at 80 °C, in addition, the relatively low operating temperature enables the material to realize in-situ loading of drugs. The cold-sintered composite with HA/PLA was 7/3 showed the best performance with significant biodegradation (16.8%) and drug release (95%) ability. Therefore, this study provides a simple and universal method for the preparation of biological composite material, which provides a useful platform for efficient in situ drug loading biomaterials.
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