Co(II) and Cu(II) Porphyrins Catalysed the Synthesis of Quinoline and Naphthoxazine via Dehydrogenative Reactions

Abstract

: In this study, we developed a facile Co (II) and Cu (II)-porphyrin catalytic system for dehydrogenative coupling reaction of benzyl alcohol with acetophenone derivatives for quinoline synthesis and intramolecular cyclisation of Betti base for naphthoxazine synthesis. Functionalized porphyrins containing ester and quinoline ring (CoTPPBenzo(NPh)) and (CuTPPBenzo(NPh)) were synthesized and confirmed via various analytical techniques. These cobalt (II) and copper (II) porphyrins were tested for the synthesis of quinolines and naphthoxazines via a dehydrogenative coupling reaction. These cobalt and copper porphyrins showed excellent catalytic activity with broad substrate scope. Additionally, a series of controlled experiments were performed to support this work.