Abstract
The Effective Perinatal Intensive Care in Europe (EPICE) cohort includes all births between 22 + 0 and 31 + 6 weeks of gestation in 2011/12 in 19 regions in 11 European countries. This cohort was set up to investigate the use of evidence-based interventions for prenatal and postnatal care of infants born very preterm (VPT) and to explore the associations between evidence-based care and their health and developmental outcomes. The first phase, ‘Effective perinatal intensive care in Europe’ (EPICE) focused on obstetric and neonatal care before and around the time of birth and during the neonatal hospitalization period, with follow-up at 2 years of corrected age (CA), while a second phase, ‘Screening for Health in Infants born very Preterm’ (SHIPS), assessed follow-up care provided in the first 5 years of life and neurodevelopmental outcomes at 5 years of age.
Highlights
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The Effective Perinatal Intensive Care in Europe (EPICE) cohort includes all births between 22 þ 0 and 31 þ 6 weeks of gestation in 2011/12 in 19 regions in 11 European countries
Both phases were funded by the European Union [Seventh Framework Programme. Both phases are based on the premise that survival, neurodevelopmental outcome and health-related quality of life can be improved for children born VPT by promoting the use of evidence-based health care. Improving these outcomes is important as VPT birth, occurring in about 1–2% of births, constitutes one of the principal determinants of infant mortality and morbidity, accounting for up to 75% of neonatal deaths in 2015.1 Further, despite significant medical advances in survival over recent decades, after discharge from the neonatal intensive care unit (NICU), survivors of VPT birth remain at high risk of neurodevelopmental impairment, including cerebral palsy, cognitive impairment, visual and auditory deficits and behavioural problems
Summary
Jennifer Zeitlin ,1* Rolf F Maier,[2] Marina Cuttini,[3] Ulrika Aden,[4] Klaus Boerch,[5] Janusz Gadzinowski,[6] Pierre-Henri Jarreau,[7] Jo Lebeer,[8] Mikael Norman,[9,10] Pernille Pedersen,[11] Stavros Petrou,[12,13] Johanna M Pfeil,[14] Liis Toome,[15] Arno van Heijst,[16] Patrick Van Reempts,[17] Heili Varendi,[18] Henrique Barros[19] and Elizabeth S Draper[20] for the EPICE and SHIPS Research Groups.
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