Abstract
Cognitive Behavioral Tests May Predict Eye Affection in High-Fat Diet Induced Pre-Obese Mice: Implications for Diabetic Retinopathy
Highlights
Obesity-related type 2 diabetes mellitus (T2DM) is associated with a metabolic syndrome encompassing hyperglycemia and other detrimental systemic changes resulting in severe microvascular complications like diabetic retinopathy (DR) [1,2]
DR has two major stages: (i) Non-Proliferative DR (NPDR) that is associated with blood vessel malfunction resulting in edema and ischemia in the retina; and (ii) Proliferative DR (PDR) where an aberrant neovascularization is observed in the retina, leading to retinal detachment and vision loss [2,3]
The findings of the present study suggest that physiological parameters and behavioral indicators of cognitive impairment can be used as predictors of eye affections in metabolically challenged mice
Summary
Obesity-related type 2 diabetes mellitus (T2DM) is associated with a metabolic syndrome encompassing hyperglycemia and other detrimental systemic changes resulting in severe microvascular complications like diabetic retinopathy (DR) [1,2]. DR has two major stages: (i) Non-Proliferative DR (NPDR) that is associated with blood vessel malfunction resulting in edema and ischemia in the retina; and (ii) Proliferative DR (PDR) where an aberrant neovascularization is observed in the retina, leading to retinal detachment and vision loss [2,3]. DR is a leading cause of vision loss worldwide [4,5]. Indicators of progression to diabetic retinopathy (DR) are needed in type 2 diabetes mellitus (T2DM) obese patients. We assessed the predictive power of cognitive function indicators for eye involvement in high fat diet (HFD)induced pre-obese mice
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