Abstract
Background: Lung cancer is a major cause of cancer death worldwide. The incidence of lung cancer in Thailand increasing, but risk factors are rarely reported. Objective:To investigate the effect of coffee consumption on lung cancer in Thai population. Methods:Between 1990 and 2001, lifestyle and demographic data were collected from 24,528 participants in the Khon Kaen Cohort Study (KKCS), who were followed through 2016, by linking to the Khon Kaen Population-based Cancer Registry. A total of 12,668 eligible participants (68.8% females, mean age 51.0 years at baseline) having complete datasets (239,488 person-years of follow up with 138 incident cases of lung cancer observed) were analyzed using a multi-variable adjusted Cox proportional hazard models. Results:Coffee consumption was associated with reduced risk for lung cancer (adj. HR = 0.54; 95% CI: 0.35-0.84) after adjusting for age and gender. Cigarette smoking (adj. HR = 2.76; 95% CI: 1.32-5.78) and family history of cancer (adj. HR = 1.65; 95% CI: 1.10-2.48) were associated with higher risk. Conclusion:This study suggests coffee consumption may be a protective factor for lung cancer in among this cohort.
Highlights
In 2018, it is estimated that over 2 million new cases of lung cancer were diagnosed globally, while more than 1.7 million deaths occurred the highest among all cancers (Bray et al, 2018)
Between 1990 and 2001, lifestyle and demographic data were collected from 24,528 participants in the Khon Kaen Cohort Study (KKCS), who were followed through 2016, by linking to the Khon Kaen Population-based Cancer Registry
This study suggests coffee consumption may be a protective factor for lung cancer in among this cohort
Summary
In 2018, it is estimated that over 2 million new cases of lung cancer were diagnosed globally, while more than 1.7 million deaths occurred the highest among all cancers (Bray et al, 2018). A well-known risk factor for lung cancer is tobacco smoking (Li et al, 2017). Coffee consumption has been studied for its association with lung cancer risk. The case-control studies in Thailand reported that chronic exposure to radon and cigarettes smoking increased risk of lung cancer (Pisani et al, 2006; Autsavapromporn et al, 2018). No cohort study addressing risk factors of lung cancer in Thai population. The aim of this study was to investigate the effects of coffee consumption on lung cancer in Thai population. Objective: To investigate the effect of coffee consumption on lung cancer in Thai population. Results: Coffee consumption was associated with reduced risk for lung cancer Conclusion: This study suggests coffee consumption may be a protective factor for lung cancer in among this cohort
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
