Abstract
Coenzyme Q10 (CoQ10) is a naturally occurring vitamin-like substance that plays a key role in the normal functioning of the cardiovascular system. Recent randomised controlled clinical studies (Q-SYMBIO and KISEL-10) comprising more than 400 patients have demonstrated significant benefits of long-term CoQ10 supplementation for the treatment or prevention of cardiovascular disease respectively. In the Q-SYMBIO study, CoQ10 supplementation (3 x 100 mg/day) over a 2-year period in patients with chronic heart failure reduced cardiovascular mortality risk by 43%. In the KISEL-10 study, supplementation with a combination of CoQ10 (200 mg/day) and selenium (200 mcg/day) over a 5-year period in the normal elderly population reduced cardiovascular mortality risk by 53%. No significant adverse effects were reported in either the Q-SYMBIO or KISEL-10 studies. The specific form of CoQ10 used in the Q-SYMBIO and KISEL-10 studies addresses previous concerns regarding issues of product quality, safety and variable efficacy in the management of cardiovascular disease.
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