Abstract

Background: The possibility of an association between Multiple Sclerosis (MS) and cancer has not been thoroughly investigated. Case Presentation: We present a case of ovarian cancer in 58-year-old woman with MS. Radical hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and pelvic and para-aortic lymph node dissection was performed. Pathohistological analysis and immunohistochemistry confirmed the diagnosis of a clear cell carcinoma of the left ovary, grade Ⅲ, FIGO2014 stage IA. Adjuvant chemotherapy of paclitaxel-carboplatin regimen (paclitaxel 175mg/m2, carboplatin AUC 6, at intervals of 3 weeks) was implemented for 4 courses. Conclusion: The occurrence of ovarian cancer in MS patients may be coincidental. Nevertheless, the longterm use of immunosuppressive and/or immunomodulatory drugs in MS and the incidence of cancer may be associated.

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