Clustered intraepidermal lymphocytes and Langerhans cell microgranulomas are consistently observed in hyperkeratotic palmoplantar eczema compared with palmoplantar psoriasis and mycosis fungoides palmaris et plantaris

Abstract

To the Editor: Hyperkeratotic palmoplantar eczema (HPE) is a chronic condition that is characterized by sharply demarcated hyperkeratosis, often with painful fissuring, typically seen on the palm of the hands or volar surface of the fingers.1 Palmar hyperkeratosis is also seen in other dermatoses, including palmoplantar psoriasis (PP) and mycosis fungoides of the palms (mycosis fungoides palmaris et plantaris [MFPP]). To assess for microscopic features specific for a given entity, 12 cases of HPE, 5 cases of PP, and 9 cases of MFPP with characteristic clinical and histopathologic features were selected retrospectively.