Closing the Gap: A Randomized Trial Targeting Daily Living Skills in Autistic Adolescents.

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Autistic adolescents without an intellectual disability (ID) have daily living skills (DLS) that are approximately 6 years below peers. This study evaluated the efficacy of the Surviving and Thriving in the Real World (STRW) intervention, which targets DLS, compared to an active control group. Autistic adolescents were randomized to STRW or control. The primary outcome was the caregiver-reported Vineland Adaptive Behavior Scales, 3rd Edition (VABS-3) DLS domain and Personal, Domestic, and Community sub-domains. The secondary outcome was DLS Goal Attainment Scaling (DLS-GAS) caregiver interview. Compared to control (n = 22), autistic teens in STRW (n = 26) made significant improvements on the VABS-3 DLS domain (p = .04) and Domestic sub-domain (p = .01) and the DLS-GAS areas of Cooking, Laundry, and Money Management (all p's < .05). STRW narrowed the gap between DLS and age as autistic adolescents acquired age-appropriate domestic, personal, and community DLS compared to the control group.

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Study protocol for a multimethod investigation of the development of social and nonsocial reward responsivity and depression in autistic adolescents: Reward and Depression in Autism (RDA)
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BackgroundAutistic adolescents are more likely to experience depression than their non-autistic peers, yet risk factors for depression in autistic adolescents are not well understood. Better mechanistic knowledge of depression in autistic adolescents is critical to understanding higher prevalence rates and developing targeted interventions. Altered reward responsiveness and social processes, as assessed by clinical and neural measures [i.e., electroencephalography (EEG)], are important risk factors for depression in non-autistic adolescents that remain largely unexplored in autistic adolescents, even though autistic people have higher rates of depression, exhibit reward differences, and often experience difficulties in social interactions. Therefore, a multimethod investigation of social and nonsocial reward responsivity and their associations with depression symptoms in autistic adolescents, particularly over time, is needed.MethodsThe current project will employ clinical and neural measures (i.e., interviews, EEG tasks) of social and nonsocial reward responsivity and depression to test associations between these constructs in autistic adolescents for the first time. A clinical sample of 100 autistic adolescents (14–17 years old) without intellectual disability and with varying severity of depression symptoms (at least 50% with current depression) will be recruited. Clinical and neural measures will be administered at two timepoints one year apart. Planned analyses will test cross-sectional and longitudinal relations between clinical and neural measures of reward responsivity and depression symptoms.DiscussionThis systematic study of reward responsivity and depression in autistic adolescents is likely to advance our collective understanding of depression in this population by informing risk stratification models and identifying potential intervention targets. Findings may also establish the reliability of several clinical and neural measures of reward responsivity in this population that can eventually be used to measure treatment outcome and identify predictors of treatment response.

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