Abstract

We report the cloning and expression of a novel 5-HT receptor gene from human genomic DNA. This clone, HGCR1, contains an apparently intronless open reading frame of 390 amino acids with the seven hydrophobic regions, typical of G-protein coupled receptors. The deduced amino acid sequence of HGCR1 is 39%, 55% and 87% identical to that for the human 5-HT 1A, the human 5-HT 1D and the rat 5-HT 1B receptor, respectively. [ 3H]5-HT binding to transfected COS-7 cell membranes yields a pharmacological profile similar to that of 5-HT 1B receptor. Thus these findings indicate the presence of 5-HT 1B-type receptor in the human.

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