Abstract
Clonidine poisoning remains a significant concern in pediatric emergency medicine. Clonidine has α-2 adrenergic agonist activity that decreases norepinephrine release centrally in the brainstem. Clinical findings include lethargy, coma, bradycardia, hypotension, respiratory depression, and occasionally, transient hypertension. Proposed specific therapies include administration of naloxone, tolazoline, and yohimbine. Additional focused treatments include atropine for bradycardia, pressors for hypertension, and antihypertensive agents for hypertension. This article discusses the effectiveness of these therapies for clonidine poisoning based on reported experience.
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