Abstract
BackgroundCervical cancer is one of the common gynecological malignancies with a high recurrence rate after surgery. This study aimed to analyze the clinicopathological risk factors for recurrence after the surgical treatment of cervical cancer and provide the basis for the prevention of recurrence and an improvement of prognosis.MethodsA total of 424 cervical cancer cases between 1 January 1998 and 31 December 2011 undergoing surgical treatment were studied retrospectively, of which 23 cases had recurrences. Relevant recurrence risk factors were evaluated by univariate and multivariate analyses between recurrence group and non-recurrence group.ResultsUsing univariate analysis, tumor differentiation, clinical stage, pelvic lymph node metastasis, postoperative radiotherapy and postoperative chemotherapy were related to recurrence of cervical cancer. Multivariate COX model analysis revealed that pelvic lymph node metastasis and postoperative chemotherapy had an impact on recurrence rate. Moderately and highly differentiated tumor, advanced clinical stage, and positive pelvic lymph nodes indicated a high recurrence rate of cervical cancer. Postoperative chemotherapy and radiotherapy can effectively reduce the recurrence rate.ConclusionsIn conclusion, cervical lymph node metastasis and postoperative chemotherapy are two independent factors for recurrence of cervical cancer after radical surgery.
Highlights
Cervical cancer is one of the common gynecological malignancies with a high recurrence rate after surgery
Clinical data of postoperative recurrence All 424 patients enrolled in this study experienced surgical treatment, and recurrence occurred in 23 cases
Data showed that tumor histological grade (P < 0.001) and clinical stage (P < 0.001) were well correlated with cervical cancer recurrence after surgery
Summary
Cervical cancer is one of the common gynecological malignancies with a high recurrence rate after surgery. Though the application of surgery and adjuvant therapy, early cervical cancer patients have a high survival rate, especially for type Ib and IIa patients, with the 5-year survival rate up to about 75 to 90% [4]. Those with a large cervical lesion or positive pelvic lymph nodes are usually treated with a combination of radiotherapy with concomitant chemotherapy. Cervical cancer recurrence can be affected by many factors, such as clinical stage, histological type, histological grade, treatment method, self-status, and others [6,7] Evaluating these factors and looking for an effective treatment to improve the recurrence rate has become a hot topic for gynecologic oncology. We aimed to find out the clinical and pathological risk factors for cervical cancer recurrence through retrospective analysis of 424 cervical cancer patients undergoing radical hysterectomy
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