Abstract
Objective To study postoperative monitoring value of serum Golgi protein 73 (GP73) in the primary hepatic carcinoma.Methods Serum GP73 was detected by using ELISA,in 63 patients with primary liver cancer,before surgery,2 and 4 weeks after operation and 21 recurrent cases who were readmitted 3-12 months later.Results In primary liver cancer patients before surgery average concentration of GP73 was (240.5 ± 81.4) ng/ml,while 2 weeks after surgical treatment the average concentration of GP73 was (114.4 ± 34.1) ng/ml,after 4 weeks was (57.6 ± 23.3) ng/ml,concentration of GP73 before treatment were significantly higher than the concentration after treatment (P ＜ 0.05).GP73 concentration [(181.2 ±72.4) ng/ml] in patients with recurrence of hepatocellular carcinoma was significantly higher than the concentration after treatment (P ＜ 0.05).Conclusion GP73 is a new serum biomarker of hepatocellular carcinoma and had a good performance in monitoring prognosis of patients with hepatocellular carcinoma. Key words: Golgi apparatus ; Prognosis ; Liver neoplasms
Published Version
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